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Expression profiling in N2 (wild-type) early embryo

ABSTRACT: Determination of gene expression levels in wild-type early embryo. First published in Rechtsteiner et al. 2010 PLoS Genetics. 4 replicates of total RNA from wild-type early embryo

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Susan Strome

PROVIDER: E-GEOD-58759 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny.

Rechtsteiner Andreas A Ercan Sevinc S Takasaki Teruaki T Phippen Taryn M TM Egelhofer Thea A TA Wang Wenchao W Kimura Hiroshi H Lieb Jason D JD Strome Susan S

PLoS genetics 20100902 9

Methylation of histone H3K36 in higher eukaryotes is mediated by multiple methyltransferases. Set2-related H3K36 methyltransferases are targeted to genes by association with RNA Polymerase II and are involved in preventing aberrant transcription initiation within the body of genes. The targeting and roles of the NSD family of mammalian H3K36 methyltransferases, known to be involved in human developmental disorders and oncogenesis, are not known. We used genome-wide chromatin immunoprecipitation ...[more]

PMID: 20824077

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