Unknown,Transcriptomics,Genomics,Proteomics

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Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome


ABSTRACT: This study uses Whole Transcriptome Shotgun Sequencing (RNA-Seq) data to interrogate the developmental dynamics of the C57BL/6 mouse liver transcriptome. We analyze gene expression patterns in the developing mouse liver over 12 distinct time points from late embryonic stage (2 days before birth) to maturity (60 days after birth). Biological functions deemed significant at different developmental stages are identified and their leverage is mapped over time. Upstream regulators modulating these gene expression patterns are determined and their regulatory networks are described along with putative transcriptional modules associated with gene regulation. Several genes that were alternatively spliced over time were identified. Previously uncharacterized isoforms were found for several genes. We analyze gene expression patterns in the developing mouse liver over 12 distinct time points from late embryonic stage (2 days before birth) to maturity (60 days after birth). Three replicates per time point.

ORGANISM(S): Mus musculus

SUBMITTER: Curtis Klaassen 

PROVIDER: E-GEOD-58827 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Ontogeny of hepatic energy metabolism genes in mice as revealed by RNA-sequencing.

Renaud Helen J HJ   Cui Yue Julia YJ   Lu Hong H   Zhong Xiao-bo XB   Klaassen Curtis D CD  

PloS one 20140807 8


The liver plays a central role in metabolic homeostasis by coordinating synthesis, storage, breakdown, and redistribution of nutrients. Hepatic energy metabolism is dynamically regulated throughout different life stages due to different demands for energy during growth and development. However, changes in gene expression patterns throughout ontogeny for factors important in hepatic energy metabolism are not well understood. We performed detailed transcript analysis of energy metabolism genes dur  ...[more]

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