Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Susanne Walz
PROVIDER: E-GEOD-59001 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Muthalagu Nathiya N Junttila Melissa R MR Wiese Katrin E KE Wolf Elmar E Morton Jennifer J Bauer Barbara B Evan Gerard I GI Eilers Martin M Murphy Daniel J DJ
Cell reports 20140828 5
MYC is one of the most frequently overexpressed oncogenes in human cancer, and even modestly deregulated MYC can initiate ectopic proliferation in many postmitotic cell types in vivo. Sensitization of cells to apoptosis limits MYC's oncogenic potential. However, the mechanism through which MYC induces apoptosis is controversial. Some studies implicate p19ARF-mediated stabilization of p53, followed by induction of proapoptotic BH3 proteins NOXA and PUMA, whereas others argue for direct regulation ...[more]