HOX genes: potential candidates furthering the development of larynx squamous cell carcinoma.

ABSTRACT: Larynx squamous cell carcinoma (LSCC) is the second most aggressive cancer from head and neck (HSCC). Survival of LSCC patients has been found worsening, albeit significant advances in technology and therapeutics were made. We sought to clarify new genetic targets driven the development of LSCC. Analyzing tumors revealed that eight members of the homeobox gene family (HOX) were expressed 200 times more in LSCC samples than in normal larynx tissue. qPCR analysis validated all transcriptomic findings for the HOX gene family. Receiver Operating Characteristic statistical method (ROC curve) predicted that 8 members of the HOX gene family differentiate tumors from their normal surrounding tissue. Enabling the comparison of patient clinics with gene expression data, ROC curve analysis yet reveal

ORGANISM(S): Homo sapiens

SUBMITTER: Wilson Silva Jr 

PROVIDER: E-GEOD-59102 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress