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Profiling of mRNA N6-Adenosine Methylation (m6A) in Arabidopsis

ABSTRACT: m6A profiling in two accessions of Arabidopsis thaliana (Can-0 and Hen-16) using the m6A-targeted antibody coupled with high-throughput sequencing m6A-seq in two accessions of Arabidopsis, two replicates for each sample

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Guan-Zheng Luo

PROVIDER: E-GEOD-59154 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Unique features of the m6A methylome in Arabidopsis thaliana.

Luo Guan-Zheng GZ MacQueen Alice A Zheng Guanqun G Duan Hongchao H Dore Louis C LC Lu Zhike Z Liu Jun J Chen Kai K Jia Guifang G Bergelson Joy J He Chuan C

Nature communications 20141128

Recent discoveries of reversible N(6)-methyladenosine (m(6)A) methylation on messenger RNA (mRNA) and mapping of m(6)A methylomes in mammals and yeast have revealed potential regulatory functions of this RNA modification. In plants, defects in m(6)A methyltransferase cause an embryo-lethal phenotype, suggesting a critical role of m(6)A in plant development. Here, we profile m(6)A transcriptome-wide in two accessions of Arabidopsis thaliana and reveal that m(6)A is a highly conserved modification ...[more]

PMID: 25430002

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