Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiles of dasatinib-resistant and dasatinib-sensitive pancreatic cancer cell lines


ABSTRACT: Gene profiles from three dasatinib-resistant and three dasatinib-sensitive pancreatic cancer cell lines were compared by microarray analysis. RNA from three dasatinib-resistant (MiaPaCa2, Panc1, SU8686) and three dasatinib-sensitive (Panc0504, Panc0403, Panc1005) pancreatic cancer cell lines were extracted. Biological triplicates were employed for each cell line. Complementary DNA microarray analysis was performed using Illumina Human HT-12 v4 BeadChip (Illumina, San Diego, CA) at the National University of Singapore Core Facility following the manufacturer’s instructions.

ORGANISM(S): Homo sapiens

SUBMITTER: Chien Wen-Wen 

PROVIDER: E-GEOD-59357 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


We utilized three tiers of screening to identify novel therapeutic agents for pancreatic cancers. First, we analyzed 14 pancreatic cancer cell lines against a panel of 66 small-molecule kinase inhibitors and dasatinib was the most potent. Second, we performed RNA expression analysis on 3 dasatinib-resistant and 3 dasatinib-sensitive pancreatic cancer cell lines to profile their gene expression. Third, gene profiling data was integrated with the Connectivity Map database to search for potential d  ...[more]

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