Unknown,Transcriptomics,Genomics,Proteomics

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Schizosaccharomyces pombe ployg mutant cells expression profile.


ABSTRACT: Expression profiles of polg mutant cells reveal that many genes encoding proteins involved in cell wall biogenesis and stress response are induced, suggesting that polg mutant cells attempt to maintain growth potential and undergo extensive oxidative metabolism. Conversely, many genes encoding proteins involved in ribosome biogenesis and respiration are repressed, indicating that cells depleted of mtDNA are adapted to grow slowly in absence of mitochondrial function. We analyzed 5 arrays of polyg mutant cells vs wild type cells.

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Zhaoqing Chu 

PROVIDER: E-GEOD-5941 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Adaptive expression responses in the Pol-gamma null strain of S. pombe depleted of mitochondrial genome.

Chu Zhaoqing Z   Li Juntao J   Eshaghi Majid M   Karuturi R Krishna Murthy RK   Lin Kui K   Liu Jianhua J  

BMC genomics 20070915


<h4>Background</h4>DNA polymerase gamma(Pol-gamma) has been shown to be essential for maintenance of the mitochondrial genome (mtDNA) in the petite-positive budding yeast Saccharomyces cerevisiae. Budding yeast cells lacking mitochondria exhibit a slow-growing or petite-colony phenotype. Petite strains fail to grow on non-fermentable carbon sources. However, it is not clear whether the Pol-gamma is required for mtDNA maintenance in the petite-negative fission yeast Schizosaccharomyces pombe.<h4>  ...[more]

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