Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Effect of PML/RARA on the transcriptome of preleukemic early promyelocytes vs PML/RARA-Flt3ITD leukemic promyelocytes

ABSTRACT: Transcriptional profiling of murine cells expressing PML/RARA at the early promyelocyte stage (4 weeks old, preleukemic) and in full blown PML/RARA leukemia generated by transducing PML/RARA bone marrow with a Flt3-ITD retroviral vector Two-conditions experiment: preleukemic early promyelocytes vs leukemic promyelocytes

ORGANISM(S): Mus musculus

SUBMITTER: Scott Kogan 

PROVIDER: E-GEOD-59431 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.

Gaillard Coline C   Tokuyasu Taku A TA   Rosen Galit G   Sotzen Jason J   Vitaliano-Prunier Adeline A   Roy Ritu R   Passegué Emmanuelle E   de Thé Hugues H   Figueroa Maria E ME   Kogan Scott C SC  

Haematologica 20150618 8

Acute promyelocytic leukemia is an aggressive malignancy characterized by the accumulation of promyelocytes in the bone marrow. PML/RARA is the primary abnormality implicated in this pathology, but the mechanisms by which this chimeric fusion protein initiates disease are incompletely understood. Identifying PML/RARA targets in vivo is critical for comprehending the road to pathogenesis. Utilizing a novel sorting strategy, we isolated highly purified promyelocyte populations from normal and youn  ...[more]