Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Scott Kogan
PROVIDER: E-GEOD-59431 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gaillard Coline C Tokuyasu Taku A TA Rosen Galit G Sotzen Jason J Vitaliano-Prunier Adeline A Roy Ritu R Passegué Emmanuelle E de Thé Hugues H Figueroa Maria E ME Kogan Scott C SC
Haematologica 20150618 8
Acute promyelocytic leukemia is an aggressive malignancy characterized by the accumulation of promyelocytes in the bone marrow. PML/RARA is the primary abnormality implicated in this pathology, but the mechanisms by which this chimeric fusion protein initiates disease are incompletely understood. Identifying PML/RARA targets in vivo is critical for comprehending the road to pathogenesis. Utilizing a novel sorting strategy, we isolated highly purified promyelocyte populations from normal and youn ...[more]