Unknown,Transcriptomics,Genomics,Proteomics

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GENOMIC ANALYSIS OF FIBROLAMELLAR HEPATOCELLULAR CARCINOMA REVEALS A UNIQUE MOLECULAR PROFILE

ABSTRACT: Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer usually developed in non-cirrhotic livers of children and young adults with unknown etiology. Treatment is limited to surgical intervention. To date, molecular pathogenesis of FLC has been poorly characterized. A cohort of FLCs was analyzed through SNP-array. GISTIC algorithm identified chromosomal aberrations. FLC tumors corresponding to 25 different patients. In all cases, tumor and corresponding non-tumor samples were frozen (-80°C) after hepatic resection at diagnosis. Comparative Genomic Hybridization analysis was done using Illumina HumanHap370CNV Genotyping BeadChip SNP array

ORGANISM(S): Homo sapiens

SUBMITTER: Sandrine Imbeaud 

PROVIDER: E-GEOD-59443 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Background & aims</h4>Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer that develops in children and young adults without cirrhosis. Little is known about its pathogenesis, and it can be treated only with surgery. We performed an integrative genomic analysis of a large series of patients with FLC to identify associated genetic factors.<h4>Methods</h4>By using 78 clinically annotated FLC samples, we performed whole-transcriptome (n = 58), single-nucleotide polymor  ...[more]

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