Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Karine Merienne
PROVIDER: E-GEOD-59570 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Achour Mayada M Le Gras Stéphanie S Keime Céline C Parmentier Frédéric F Lejeune François-Xavier FX Boutillier Anne-Laurence AL Néri Christian C Davidson Irwin I Merienne Karine K
Human molecular genetics 20150317 12
Huntington's disease (HD) is a neurodegenerative disease associated with extensive down-regulation of genes controlling neuronal function, particularly in the striatum. Whether altered epigenetic regulation underlies transcriptional defects in HD is unclear. Integrating RNA-sequencing (RNA-seq) and chromatin-immunoprecipitation followed by massively parallel sequencing (ChIP-seq), we show that down-regulated genes in HD mouse striatum associate with selective decrease in H3K27ac, a mark of activ ...[more]