Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: yuanyuan zha
PROVIDER: E-GEOD-5960 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zha Yuanyuan Y Marks Reinhard R Ho Allen W AW Peterson Amy C AC Janardhan Sujit S Brown Ian I Praveen Kesavannair K Stang Stacey S Stone James C JC Gajewski Thomas F TF
Nature immunology 20061008 11
T cell anergy has been correlated with defective signaling by the GTPase Ras, but causal and mechanistic data linking defective Ras activity with T cell anergy are lacking. Here we used adenoviral transduction to genetically manipulate nonproliferating T cells and show that active Ras restored interleukin 2 production and mitogen-activated protein kinase signaling in T cells that were made anergic in vitro or in vivo. Diacylglycerol kinases (DGKs), which negatively regulate Ras activity, were up ...[more]