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GIST cell cycle dysregulation is required for progression to high-risk disease but not for resistance to kinase inhibitors

ABSTRACT: Background: To understand the transcriptional consequences of a TP53 modulation in the GIST cell context, we treated GIST430 with increasing doses of the MDM2-inhibitor nutlin-3 (racemate). In this study, 3’ end RNA Sequencing (3SEQ) was used to expression profile GIST430 cell lines treated with DMSO and Nutlin-3, 2.5µM or 10µM for 18h. Then the gene expression profiles between these concentrations were compared.

ORGANISM(S): Homo sapiens

SUBMITTER: Xiangqian Guo

PROVIDER: E-GEOD-59841 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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GIST cell cycle dysregulation is required for progression to high-risk disease but not for resistance to kinase inhibitors

Project description:Background: To understand the transcriptional consequences of a TP53 modulation in the GIST cell context, we treated GIST430 with increasing doses of the MDM2-inhibitor nutlin-3 (racemate).

2014-12-25 | GSE59841 | GEO

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