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Stockholm dataset for ageing prototype diagnostic

ABSTRACT: Muscle biopsy samples from healthy male subjects at the baseline belonging to either <29y or >59y age range. These samples were used to design a prototype of multi-tissue molecular diagnostic of healthy physiological age. Resting skeletal muscle sample after an overnight fast. related to GSE18583

ORGANISM(S): Homo sapiens

SUBMITTER: Jamie Timmons

PROVIDER: E-GEOD-59880 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype.

Keller Pernille P Vollaard Niels B J NB Gustafsson Thomas T Gallagher Iain J IJ Sundberg Carl Johan CJ Rankinen Tuomo T Britton Steven L SL Bouchard Claude C Koch Lauren G LG Timmons James A JA

Journal of applied physiology (Bethesda, Md. : 1985) 20101007 1

The molecular pathways that are activated and contribute to physiological remodeling of skeletal muscle in response to endurance exercise have not been fully characterized. We previously reported that ∼800 gene transcripts are regulated following 6 wk of supervised endurance training in young sedentary males, referred to as the training-responsive transcriptome (TRT) (Timmons JA et al. J Appl Physiol 108: 1487-1496, 2010). Here we utilized this database together with data on biological variation ...[more]

PMID: 20930125

Publication: 1/2

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