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Gene expression profiling of dectin-1 and NFAT responsive genes in dendritic cells

ABSTRACT: This study provides the dectin-1 and NFAT responsive genes for 2h and 4h of curdlan treatment. Affymetrix Mouse Gene 1.0ST Arrays were used to profile gene expression in curdlan-stimulated D1 cells (2h or 4h exposure) that had been treated or not with FK506 for the duration of culture. Dendritic cell line D1 was treated with curdlan for 2h and 4h, and curdlan + Fk506 for 2h and 4h in three replicate.

ORGANISM(S): Mus musculus

SUBMITTER: Marina Yurieva 

PROVIDER: E-GEOD-59896 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

NFATc2 mediates epigenetic modification of dendritic cell cytokine and chemokine responses to dectin-1 stimulation.

Yu Hong-Bing HB   Yurieva Marina M   Balachander Akhila A   Foo Ivy I   Leong Xiangrong X   Zelante Teresa T   Zolezzi Francesca F   Poidinger Michael M   Ricciardi-Castagnoli Paola P  

Nucleic acids research 20141230 2

The transcription factor NFATc2 regulates dendritic cell (DC) responses to microbial stimulation through the C-type lectin receptor dectin-1. But the genetic targets of NFATc2 and their effects on DC function remain largely unknown. Therefore we used ChIP-seq to conduct genome-wide mapping of NFATc2 target sites in dectin-1-activated DCs. By combining binding-site data with a comprehensive gene expression profile, we found that NFATc2 occupancy regulates the expression of a subset of dectin-1-ac  ...[more]

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