Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: James Wells
PROVIDER: E-GEOD-59928 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jonatan Diva D Spence Jason R JR Method Anna M AM Kofron Matthew M Sinagoga Katie K Haataja Leena L Arvan Peter P Deutsch Gail H GH Wells James M JM
PloS one 20140821 8
SOX17 is a key transcriptional regulator that can act by regulating other transcription factors including HNF1β and FOXA2, which are known to regulate postnatal β cell function. Given this, we investigated the role of SOX17 in the developing and postnatal pancreas and found a novel role for SOX17 in regulating insulin secretion. Deletion of the Sox17 gene in the pancreas (Sox17-paLOF) had no observable impact on pancreas development. However, Sox17-paLOF mice had higher islet proinsulin protein ...[more]