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Genome-wide analysis of high glucose and DZNep (EZH2 inhibitor) induced gene expression by mouse podocytes

ABSTRACT: Analysis of DZNep-induced gene expression changes in cultured podocytes. The hypothesis tested in the present study was that DZnep ultimately augments Txnip expression, increasing oxidative stress in podocytes. These results provide important information on the response of podocytes to histone methyltransferase inhibition and a possible mechanism for DZNep action in podocytes. Total RNA obtained from cultured podocytes subjected to 48 hours in vitro, with or without DZNep.

ORGANISM(S): Mus musculus

SUBMITTER: Andrew Advani 

PROVIDER: E-GEOD-60038 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The Histone Methyltransferase Enzyme Enhancer of Zeste Homolog 2 Protects against Podocyte Oxidative Stress and Renal Injury in Diabetes.

Siddiqi Ferhan S FS   Majumder Syamantak S   Thai Kerri K   Abdalla Moustafa M   Hu Pingzhao P   Advani Suzanne L SL   White Kathryn E KE   Bowskill Bridgit B BB   Guarna Giuliana G   Dos Santos Claudia C CC   Connelly Kim A KA   Advani Andrew A  

Journal of the American Society of Nephrology : JASN 20151103 7

Epigenetic regulation of oxidative stress is emerging as a critical mediator of diabetic nephropathy. In diabetes, oxidative damage occurs when there is an imbalance between reactive oxygen species generation and enzymatic antioxidant repair. Here, we investigated the function of the histone methyltransferase enzyme enhancer of zeste homolog 2 (EZH2) in attenuating oxidative injury in podocytes, focusing on its regulation of the endogenous antioxidant inhibitor thioredoxin interacting protein (T  ...[more]

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