Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Caroline Friedel
PROVIDER: E-GEOD-60040 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rutkowski Andrzej J AJ Erhard Florian F L'Hernault Anne A Bonfert Thomas T Schilhabel Markus M Crump Colin C Rosenstiel Philip P Efstathiou Stacey S Zimmer Ralf R Friedel Caroline C CC Dölken Lars L
Nature communications 20150520
Herpes simplex virus 1 (HSV-1) is an important human pathogen and a paradigm for virus-induced host shut-off. Here we show that global changes in transcription and RNA processing and their impact on translation can be analysed in a single experimental setting by applying 4sU-tagging of newly transcribed RNA and ribosome profiling to lytic HSV-1 infection. Unexpectedly, we find that HSV-1 triggers the disruption of transcription termination of cellular, but not viral, genes. This results in exten ...[more]