Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kazuhiko Nakabayashi
PROVIDER: E-GEOD-60044 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Murakami Masanori M Yoshimoto Takanobu T Nakabayashi Kazuhiko K Tsuchiya Kyoichiro K Minami Isao I Bouchi Ryotaro R Izumiyama Hajime H Fujii Yasuhisa Y Abe Kosei K Tayama Chiharu C Hashimoto Koshi K Suganami Takayoshi T Hata Ken-ichiro K Kihara Kazunori K Ogawa Yoshihiro Y
European journal of endocrinology 20150507 2
<h4>Objective</h4>The pathophysiology of aldosterone-producing adenomas (APA) has been investigated intensively through genetic and genomic approaches. However, the role of epigenetics in APA is not fully understood. In the present study, we explored the relationship between gene expression and DNA methylation status in APA.<h4>Methods</h4>We conducted an integrated analysis of transcriptome and methylome data of paired APA-adjacent adrenal gland (AAG) samples from the same patient. The adrenal ...[more]