Unknown,Transcriptomics,Genomics,Proteomics

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Comparison of miRNA profile of activated T cells to naive T cells

ABSTRACT: T cells were activated for 1, 3 or 10 days using plate-bound anti-TCR and anti-CD28. Low molecular weight RNA from conventional T cells and activated T cells was hybridised to microarrays containing oligonucleotide probes corresponding to known miRNA sequences. Keywords: cell state analysis Five arrays, with T cells having been activated for varying lengths of time, including dye swaps.

ORGANISM(S): Mus musculus

SUBMITTER: Bradley Cobb 

PROVIDER: E-GEOD-6006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell-like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer  ...[more]

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