Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human ovarian tumors and normal ovaries


ABSTRACT: 99 individual ovarian tumors (37 endometrioid, 41 serous, 13 mucinous, and 8 clear cell carcinomas) and 4 individual normal ovary samples, each assayed on an Affymetrix HG_U133A array Experiment Overall Design: 99 individual ovarian tumors (37 endometrioid, 41 serous, 13 mucinous, and 8 clear cell carcinomas) and 4 individual normal ovary samples. RNA expression was analyzed using one Affymetrix HG_U133A array per sample.

ORGANISM(S): Homo sapiens

SUBMITTER: Rork Kuick 

PROVIDER: E-GEOD-6008 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas.

Hendrix Neali D ND   Wu Rong R   Kuick Rork R   Schwartz Donald R DR   Fearon Eric R ER   Cho Kathleen R KR  

Cancer research 20060201 3


Wnt signaling plays a key role in development and adult tissues via effects on cell proliferation, motility, and differentiation. The cellular response to Wnt ligands largely depends on their ability to stabilize beta-catenin and the ability of beta-catenin to bind and activate T-cell factor (TCF) transcription factors. Roughly 40% of ovarian endometrioid adenocarcinomas (OEA) have constitutive activation of Wnt signaling as a result of oncogenic mutations in the beta-catenin protein or inactiva  ...[more]

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