Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rork Kuick
PROVIDER: E-GEOD-6008 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hendrix Neali D ND Wu Rong R Kuick Rork R Schwartz Donald R DR Fearon Eric R ER Cho Kathleen R KR
Cancer research 20060201 3
Wnt signaling plays a key role in development and adult tissues via effects on cell proliferation, motility, and differentiation. The cellular response to Wnt ligands largely depends on their ability to stabilize beta-catenin and the ability of beta-catenin to bind and activate T-cell factor (TCF) transcription factors. Roughly 40% of ovarian endometrioid adenocarcinomas (OEA) have constitutive activation of Wnt signaling as a result of oncogenic mutations in the beta-catenin protein or inactiva ...[more]