Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Susanne Kneitz
PROVIDER: E-GEOD-60081 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer cell 20150201 2
Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor biology and find therapeutic leads for this subgroup, we analyzed 58 blastemal type Wilms tumors by exome and transcriptome sequencing and validated our findings in a large replication cohort. Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blaste ...[more]