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Phosphate metabolism in Saccharomyces cerevisiae

ABSTRACT: Investigation of Saccharomyces cerevisiae phosphate metabolism. Cells starved for phosphate, cells grown with intermediate and high phosphate concentrations, and PHO4 mutant cells examined.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Dennis Wykoff

PROVIDER: E-GEOD-603 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes.

Springer Michael M Wykoff Dennis D DD Miller Nicole N O'Shea Erin K EK

PLoS biology 20031117 2

A cell's ability to generate different responses to different levels of stimulus is an important component of an adaptive environmental response. Transcriptional responses are frequently controlled by transcription factors regulated by phosphorylation. We demonstrate that differential phosphorylation of the budding yeast transcription factor Pho4 contributes to differential gene expression. When yeast cells are grown in high-phosphate growth medium, Pho4 is phosphorylated on four critical residu ...[more]

PMID: 14624238

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Phosphate metabolism in Saccharomyces cerevisiae

Project description:Investigation of Saccharomyces cerevisiae phosphate metabolism. Cells starved for phosphate, cells grown with intermediate and high phosphate concentrations, and PHO4 mutant cells examined. Keywords: other

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