Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Dayanidhi Raman
PROVIDER: E-GEOD-60323 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Duvall-Noelle N N Karwandyar A A Richmond A A Raman D D
Oncogene 20150518 9
Nuclear LASP-1 (LIM and SH3 protein-1) has a direct correlation with overall survival of breast cancer patients. In this study, immunohistochemical analysis of a human breast TMA showed that LASP-1 is absent in normal human breast epithelium but the expression increases with malignancy and is highly nuclear in aggressive breast cancer. We investigated whether the chemokines and growth factors present in the tumor microenvironment could trigger nuclear translocation of LASP-1.Treatment of human b ...[more]