Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Maggie Purcell
PROVIDER: E-GEOD-60340 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Purcell Maggie M Kruger Adele A Tainsky Michael A MA
Cell cycle (Georgetown, Tex.) 20140101 24
Cellular senescence is a cell cycle arrest accompanied by high expression of cyclin dependent kinase inhibitors which counteract overactive growth signals, which serves as a tumor suppressive mechanism. Senescence can be a result of telomere shortening (natural or replicative senescence) or DNA damage resulting from exogenous stressors (induced senescence). Here, we performed gene expression profiling through RNA-seq of replicative senescence, adriamycin-induced senescence, H2O2-induced senescen ...[more]