Unknown,Transcriptomics,Genomics,Proteomics

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Pathway Profiling of Replicative and Induced Senescence


ABSTRACT: RNA-seq was performed on LFS MDAH041 cells that were young (PD10-12), aging (PD17-19) and replicatively senescent (PD28-30), as well as spontaneously immortal cells and cells that were induced into senescence or quiescence, in order to profile the pathways common in all 4 types of sensecence and the pathways affected as a cell approaches senescence. RNA was sequenced in biological triplicates of each sample using the Illumina HiSeq2000

ORGANISM(S): Homo sapiens

SUBMITTER: Maggie Purcell 

PROVIDER: E-GEOD-60340 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profiling of replicative and induced senescence.

Purcell Maggie M   Kruger Adele A   Tainsky Michael A MA  

Cell cycle (Georgetown, Tex.) 20140101 24


Cellular senescence is a cell cycle arrest accompanied by high expression of cyclin dependent kinase inhibitors which counteract overactive growth signals, which serves as a tumor suppressive mechanism. Senescence can be a result of telomere shortening (natural or replicative senescence) or DNA damage resulting from exogenous stressors (induced senescence). Here, we performed gene expression profiling through RNA-seq of replicative senescence, adriamycin-induced senescence, H2O2-induced senescen  ...[more]

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