Unknown,Transcriptomics,Genomics,Proteomics

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Leukocyte gene expression variation as a function of Big 5 dimensions of human personality


ABSTRACT: Individual differences in basal leukocyte gene expression profiles as a function of Big 5 personality dimensions Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 119 healthy adults measured for the 5 major dimensions of human personality (Neuroticism, Extraversion, Openness, Agreeableness, Conscientiousness) using the NEO-FFI 60-item personality inventory. Personality measures are z-score standardized. Analyses control for major demographic characteristics (age, sex, Caucasian vs Non-Caucasian race) as well as Body Mass Index (BMI), smoking (CigDay), alcohol consumption (AlcDay), and physical activity (ExerDay, hours per day). Additional secondary analyses controlled for the presence of minor physical symptoms (MinorSymptom, e.g.,hayfever, headache), medication use (BirthControl, Antidepressant, OtherMedication), and negative affective states (NegativeAffect, standardized values of PANAS Negative Affect scale). Experiment type: Risk prediction

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Cole 

PROVIDER: E-GEOD-60491 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Personality and gene expression: Do individual differences exist in the leukocyte transcriptome?

Vedhara Kavita K   Gill Sana S   Eldesouky Lameese L   Campbell Bruce K BK   Arevalo Jesusa M G JM   Ma Jeffrey J   Cole Steven W SW  

Psychoneuroendocrinology 20141111


<h4>Background</h4>The temporal and situational stability of personality has led generations of researchers to hypothesize that personality may have enduring effects on health, but the biological mechanisms of such relationships remain poorly understood. In the present study, we utilized a functional genomics approach to examine the relationship between the 5 major dimensions of personality and patterns of gene expression as predicted by 'behavioural immune response' theory. We specifically focu  ...[more]

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