Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yu Chen
PROVIDER: E-GEOD-60612 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gao Dong D Vela Ian I Sboner Andrea A Iaquinta Phillip J PJ Karthaus Wouter R WR Gopalan Anuradha A Dowling Catherine C Wanjala Jackline N JN Undvall Eva A EA Arora Vivek K VK Wongvipat John J Kossai Myriam M Ramazanoglu Sinan S Barboza Luendreo P LP Di Wei W Cao Zhen Z Zhang Qi Fan QF Sirota Inna I Ran Leili L MacDonald Theresa Y TY Beltran Himisha H Mosquera Juan-Miguel JM Touijer Karim A KA Scardino Peter T PT Laudone Vincent P VP Curtis Kristen R KR Rathkopf Dana E DE Morris Michael J MJ Danila Daniel C DC Slovin Susan F SF Solomon Stephen B SB Eastham James A JA Chi Ping P Carver Brett B Rubin Mark A MA Scher Howard I HI Clevers Hans H Sawyers Charles L CL Chen Yu Y
Cell 20140904 1
The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells. The first seven fully characterized organoid lines recapitulate the molecular diversity of prostate cancer subtypes, including TMPRSS2-ERG fusion, SPOP mutation, SPINK1 overexpress ...[more]