Unknown,Transcriptomics,Genomics,Proteomics

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Nr1i3 is implicated in sex related differences in murine response to TCDD toxicity


ABSTRACT: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant that produces myriad toxicities across various experimental models. In rodents alone, there is huge divergence in the toxicological response across species, between strains within a species and even between sexes within a strain. This difference in sensitivities between sexes has been characterized in multiple rodent models, however with contrasting results: the severity of toxicity is greater in female rats than in males while male mice and guinea pigs are more sensitive to the effects of TCDD than females. While the presence of estrogens or androgens has a known impact on response, the specific transcriptional events that cause this difference remain unclear. We sought to characterize the transcriptional environment of male and female C57BL/6 mice treated with 500 M-NM-

ORGANISM(S): Mus musculus

SUBMITTER: Stephenie Prokopec 

PROVIDER: E-GEOD-61037 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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