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Chromatin structure dynamics of hoxa13a, hoxa13b and hoxd13a loci during zebrafish development.

ABSTRACT: We designed 4C-Seq experiments for hoxa13a, hoxa13b and hoxd13a promoters in three developmental stages in zebrafish embryos: 24, 48 and 60 hpf. 4C-seq samples for three different hox13 genes promoters in three developmental stages in zebrafish embryos: 24, 48 and 60 hpf.

ORGANISM(S): Danio rerio

SUBMITTER: Juan Tena 

PROVIDER: E-GEOD-61063 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Deep conservation of wrist and digit enhancers in fish.

Gehrke Andrew R AR   Schneider Igor I   de la Calle-Mustienes Elisa E   Tena Juan J JJ   Gomez-Marin Carlos C   Chandran Mayuri M   Nakamura Tetsuya T   Braasch Ingo I   Postlethwait John H JH   Gómez-Skarmeta José Luis JL   Shubin Neil H NH  

Proceedings of the National Academy of Sciences of the United States of America 20141222 3

There is no obvious morphological counterpart of the autopod (wrist/ankle and digits) in living fishes. Comparative molecular data may provide insight into understanding both the homology of elements and the evolutionary developmental mechanisms behind the fin to limb transition. In mouse limbs the autopod is built by a "late" phase of Hoxd and Hoxa gene expression, orchestrated by a set of enhancers located at the 5' end of each cluster. Despite a detailed mechanistic understanding of mouse lim  ...[more]

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