Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Aaron Arvey
PROVIDER: E-GEOD-61077 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Levine Andrew G AG Arvey Aaron A Jin Wei W Rudensky Alexander Y AY
Nature immunology 20140928 11
Foxp3(+) regulatory T cells (T(reg) cells) maintain immunological tolerance, and their deficiency results in fatal multiorgan autoimmunity. Although heightened signaling via the T cell antigen receptor (TCR) is critical for the differentiation of T(reg) cells, the role of TCR signaling in T(reg) cell function remains largely unknown. Here we demonstrated that inducible ablation of the TCR resulted in T(reg) cell dysfunction that could not be attributed to impaired expression of the transcription ...[more]