Loss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Guido Hooiveld
PROVIDER: E-GEOD-61100 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
p21 ablation in liver enhances DNA damage, cholestasis, and carcinogenesis.
Ehedego Haksier H Boekschoten Mark V MV Hu Wei W Doler Carina C Haybaeck Johannes J Gaβler Nikolaus N Müller Michael M Liedtke Christian C Trautwein Christian C
Cancer research 20150121 6
Genetic mouse studies suggest that the NF-κB pathway regulator NEMO (also known as IKKγ) controls chronic inflammation and carcinogenesis in the liver. However, the molecular mechanisms explaining the function of NEMO are not well defined. Here, we report that overexpression of the cell-cycle regulator p21 is a critical feature of liver inflammation and carcinogenesis caused by the loss of NEMO. NEMO(Δhepa) mice develop chronic hepatitis characterized by increased hepatocyte apoptosis and prolif ...[more]
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