Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Gopuraja Dharmalingam
PROVIDER: E-GEOD-61130 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Herranz Nicolás N Gallage Suchira S Mellone Massimiliano M Wuestefeld Torsten T Klotz Sabrina S Hanley Christopher J CJ Raguz Selina S Acosta Juan Carlos JC Innes Andrew J AJ Banito Ana A Georgilis Athena A Montoya Alex A Wolter Katharina K Dharmalingam Gopuraja G Faull Peter P Carroll Thomas T Martínez-Barbera Juan Pedro JP Cutillas Pedro P Reisinger Florian F Heikenwalder Mathias M Miller Richard A RA Withers Dominic D Zender Lars L Thomas Gareth J GJ Gil Jesús J
Nature cell biology 20150817 9
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pro-tumorigenic properties and contribute to age-related pathologies. In a drug screen to find new SASP regulators, we uncovered the mTOR inhibitor rapamycin as a potent SASP suppressor. Here we report a mechanism by which mTOR controls the SASP by differentially regulating t ...[more]