Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yang Xie
PROVIDER: E-GEOD-61197 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Augustyn Alexander A Borromeo Mark M Wang Tao T Fujimoto Junya J Shao Chunli C Dospoy Patrick D PD Lee Victoria V Tan Christopher C Sullivan James P JP Larsen Jill E JE Girard Luc L Behrens Carmen C Wistuba Ignacio I II Xie Yang Y Cobb Melanie H MH Gazdar Adi F AF Johnson Jane E JE Minna John D JD
Proceedings of the National Academy of Sciences of the United States of America 20140929 41
Aggressive neuroendocrine lung cancers, including small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), represent an understudied tumor subset that accounts for approximately 40,000 new lung cancer cases per year in the United States. No targeted therapy exists for these tumors. We determined that achaete-scute homolog 1 (ASCL1), a transcription factor required for proper development of pulmonary neuroendocrine cells, is essential for the survival of a majority of lung cancers (b ...[more]