Unknown,Transcriptomics,Genomics,Proteomics

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ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers


ABSTRACT: ChIP-Seq analysis performed on 5 ASCL1(+) cell lines and 2 ASCL1 (-) cell lines in order to understand the transcriptome of ASCL1 as it pertains to high-grade neuroendocrine lung cancers 5 ASCL1(+) lung cancer cell lines and 2 ASCL1(-) lung cancer cell lines were compared using ChIP-Seq analysis

ORGANISM(S): Homo sapiens

SUBMITTER: Yang Xie 

PROVIDER: E-GEOD-61197 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.

Augustyn Alexander A   Borromeo Mark M   Wang Tao T   Fujimoto Junya J   Shao Chunli C   Dospoy Patrick D PD   Lee Victoria V   Tan Christopher C   Sullivan James P JP   Larsen Jill E JE   Girard Luc L   Behrens Carmen C   Wistuba Ignacio I II   Xie Yang Y   Cobb Melanie H MH   Gazdar Adi F AF   Johnson Jane E JE   Minna John D JD  

Proceedings of the National Academy of Sciences of the United States of America 20140929 41


Aggressive neuroendocrine lung cancers, including small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), represent an understudied tumor subset that accounts for approximately 40,000 new lung cancer cases per year in the United States. No targeted therapy exists for these tumors. We determined that achaete-scute homolog 1 (ASCL1), a transcription factor required for proper development of pulmonary neuroendocrine cells, is essential for the survival of a majority of lung cancers (b  ...[more]

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