Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Human liver gene expression data from subjects of varying ages

ABSTRACT: N=134 human liver samples from morbidly obese patients and healthy controls were analysed by array-based mRNA expression profiling. Liver messenger RNA expression datasets from the German patients were generated on the HuGene 1.1 ST gene array The purpose of the study was to correlate these gene expression data with body mass index and with an epigenetic measure of age acceleration based on DNA methylation data. The liver samples come from subjects whose body mass index ranged from 14.8 to 70.2. Ages varied between 10 and 85. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Horvath

PROVIDER: E-GEOD-61260 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Obesity accelerates epigenetic aging of human liver.

Horvath Steve S Erhart Wiebke W Brosch Mario M Ammerpohl Ole O von Schönfels Witigo W Ahrens Markus M Heits Nils N Bell Jordana T JT Tsai Pei-Chien PC Spector Tim D TD Deloukas Panos P Siebert Reiner R Sipos Bence B Becker Thomas T Röcken Christoph C Schafmayer Clemens C Hampe Jochen J

Proceedings of the National Academy of Sciences of the United States of America 20141013 43

Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an "epigenetic clock") to study the relationship between high body mass index (BMI) and the DNA methylation ages of human blood, liver, muscle, and adipose tissue. A significant correlation between BMI and epigenetic age acceleration could only be observed for liver (r = 0.42, P = 6.8 × 10(-4) in dataset 1 ...[more]

PMID: 25313081

Dataset Information

Human liver gene expression data from subjects of varying ages

Publications

Obesity accelerates epigenetic aging of human liver.

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