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Identifying actionable targets through integrative analyses of GEM model and human prostate cancer profiling

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Jeffrey Zhao

PROVIDER: E-GEOD-61383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling.

Wanjala Jackie J Taylor Barry S BS Chapinski Caren C Hieronymus Haley H Wongvipat John J Chen Yu Y Nanjangud Gouri J GJ Schultz Nikolaus N Xie Yingqiu Y Liu Shenji S Lu Wenfu W Yang Qing Q Sander Chris C Chen Zhenbang Z Sawyers Charles L CL Carver Brett S BS

Molecular cancer therapeutics 20141107 1

Copy-number alterations (CNA) are among the most common molecular events in human prostate cancer genomes and are associated with worse prognosis. Identification of the oncogenic drivers within these CNAs is challenging due to the broad nature of these genomic gains or losses which can include large numbers of genes within a given region. Here, we profiled the genomes of four genetically engineered mouse prostate cancer models that reflect oncogenic events common in human prostate tumors, with t ...[more]

PMID: 25381262

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