The transcriptional profile of human CD8+ lung resident memory T-cells

ABSTRACT: A specialized population of memory CD8+ T-cells resides in the epithelium of the respiratory tract to maintain protection against recurring infections. These cells express CD69 and the integrin αβ7 (CD103) and correspond to tissue resident memory T-cells (TRM) also described in intestine, liver and brain. A less well characterized population of CD103- CD8+ T-cells also resides in lungs and expresses markers characteristic of effector memory T-cells (TEM). We determined the transcriptional profiles of these memory CD8+ T-cell subsets retrieved from human lung resection samples and compared these with corresponding T-cell populations from peripheral blood of the same individuals. Our results demonstrate that each of the populations exhibits a distinct transcriptional identity. We found tha

ORGANISM(S): Homo sapiens

SUBMITTER: Perry Moerland 

PROVIDER: E-GEOD-61397 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress