Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins

ABSTRACT: Unraveling the underlying mechanisms of cetuximab resistance in head and neck squamous cell carcinoma (HNSCC) is of major importance as many tumors remain non-responsive or become resistant. Out microarray results suggest that resistant cells still exhibit RAS-MAPK pathway signaling contributing to drug resistance, as witnessed by low expression of DUSP 5 and DUSP6, negative regulators of ERK1/2, and increased expression of AURKB, a key regulator of mitosis. Therefore, interrupting the RAS-MAPK pathway by an ERK1/2 inhibitor (apigenin) or an AURKB inhibitor (barasertib) might be a new strategy for overcoming cetuximab resistance in HNSCC 4 head and neck squamous cell carcinoma (HNSCC) cell lines were treated with either 15 nM cetuximab or PBS during 13 hours. For each cell line, differential gene expression was assessed between cetuximab and PBS treatments.

ORGANISM(S): Homo sapiens

SUBMITTER: Ken Op de Beeck 

PROVIDER: E-GEOD-61495 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Unraveling the underlying mechanisms of cetuximab resistance in head and neck squamous cell carcinoma (HNSCC) is of major importance as many tumors remain non-responsive or become resistant. Our microarray results suggest that "resistant" cells still exhibit RAS-MAPK pathway signaling contributing to drug resistance, as witnessed by low expression of DUSP5 and DUSP6, negative regulators of ERK1/2, and increased expression of AURKB, a key regulator of mitosis. Therefore, interrupting the RAS-MAPK  ...[more]

Similar Datasets

Transcriptomics Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins
2014-09-18 | GSE61495 | GEO
Transcriptomics Single-cell Sequencing Analysis of Head and Neck Squamous Cell Carcinoma
2022-04-01 | GSE173647 | GEO
Transcriptomics Evaluation of gene expression changes upon acquired resistance to anti-EGFR treatment in head and neck squamous cell carcinoma
2024-11-08 | GSE235417 | GEO
Genomics Nuclear miR-451a activates KDM7A and leads to cetuximab resistance in head and neck squamous cell carcinoma [ChIRP-seq]
2024-01-01 | GSE245153 | GEO
Genomics Nuclear miR-451a activates KDM7A and leads to cetuximab resistance in head and neck squamous cell carcinoma [miRNA-Seq]
2024-01-01 | GSE244948 | GEO
Transcriptomics The expression profile of Cetuximab resistance in head-and-neck squamous cell carcinoma cells.
2017-03-02 | GSE63916 | GEO
Genomics Homo sapiens
| PRJNA261312 | ENA
Transcriptomics Gene expression associated with panitumumab efficacy in squamous cell carcinoma of head and neck
2019-01-23 | GSE102995 | GEO
Transcriptomics Integrated single cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC sensitive cell lines (scRNA-Seq)
2020-05-04 | GSE137524 | GEO
Genomics Integrated single cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC sensitive cell lines
2020-05-04 | GSE135604 | GEO