Transcription profiling of a S96xSK1 yeast cross and its pool of spores.
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Daniel Bader
PROVIDER: E-GEOD-61553 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Negative feedback buffers effects of regulatory variants.
Bader Daniel M DM Wilkening Stefan S Lin Gen G Tekkedil Manu M MM Dietrich Kim K Steinmetz Lars M LM Gagneur Julien J
Molecular systems biology 20150129 1
Mechanisms conferring robustness against regulatory variants have been controversial. Previous studies suggested widespread buffering of RNA misexpression on protein levels during translation. We do not find evidence that translational buffering is common. Instead, we find extensive buffering at the level of RNA expression, exerted through negative feedback regulation acting in trans, which reduces the effect of regulatory variants on gene expression. Our approach is based on a novel experimenta ...[more]
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