Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

The cellular origin and malignant transformation of Waldenström's Macroglobulinemia

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Bruno Paiva

PROVIDER: E-GEOD-61651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The cellular origin and malignant transformation of Waldenström macroglobulinemia.

Paiva Bruno B Corchete Luis A LA Vidriales Maria-Belen MB García-Sanz Ramón R Perez Jose J JJ Aires-Mejia Irene I Sanchez Maria-Luz ML Barcena Paloma P Alignani Diego D Jimenez Cristina C Sarasquete Maria-Eugenia ME Mateos María-Victoria MV Ocio Enrique M EM Puig Noemi N Escalante Fernando F Hernández José J Cuello Rebeca R García de Coca Alfonso A Sierra Magdalena M Montes Maria-Carmen MC González-López Tomás J TJ Galende Josefina J Bárez Abelardo A Alonso José J Pardal Emilia E Orfao Alberto A Gutierrez Norma C NC San Miguel Jesús F JF

Blood 20150205 15

Although information about the molecular pathogenesis of Waldenström macroglobulinemia (WM) has significantly advanced, the precise cell of origin and the mechanisms behind WM transformation from immunoglobulin-M (IgM) monoclonal gammopathy of undetermined significance (MGUS) remain undetermined. Here, we undertook an integrative phenotypic, molecular, and genomic approach to study clonal B cells from newly diagnosed patients with IgM MGUS (n = 22), smoldering (n = 16), and symptomatic WM (n = 1 ...[more]

PMID: 25655603

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Dataset Information

The cellular origin and malignant transformation of Waldenström's Macroglobulinemia

Publications

The cellular origin and malignant transformation of Waldenström macroglobulinemia.

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