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Gene expression profiles in the heart tissues of heart-specific Bmal1 knockout mice


ABSTRACT: Mice without cardiac Bmal1 function develop severe progressive heart failure with age. To examine the mechanism underlying the failing heart phenotype observed in heart-specific Bmal1 knockout mice, microarray analyses were performed. The analyses revealed that broad classes of genes regulating cellular energy metabolism were upregulated or downregulated in the heart tissues of heart-specific Bmal1 knockout mice compared with those of control animals. Heart total RNA extracted from six animals per genotype (control and heart-specific Bmal1 knockout) was pooled and then used for a microarray analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Akira Kohsaka 

PROVIDER: E-GEOD-61787 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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