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Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma

ABSTRACT: We have investigated expressed microRNA in cryo-preserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses reveal a unique microRNA expression signature composed of 40 genes which can distinguish normal from malignant esophageal tissue. Some microRNAs could be correlated with the different clinico-pathological classifications. For example, high hsa-miR-103, -107, -23b expression correlated with poor overall disease-free survival of esophageal cancer patients. These results indicate that microRNA expression profiles are important diagnostic and prognostic markers of esophageal cancer, which might be analyzed simply using economical approaches such as RT-PCR. Keywords: microRNA, esophageal squamous cell carcinoma cancer vs adjacent normal tissues

ORGANISM(S): Homo sapiens

SUBMITTER: yong guo

PROVIDER: E-GEOD-6188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma.

Guo Yong Y Chen Zhaoli Z Zhang Liang L Zhou Fang F Shi Susheng S Feng Xiaoli X Li Baozhong B Meng Xin X Ma Xi X Luo Mingyong M Shao Kang K Li Ning N Qiu Bin B Mitchelson Keith K Cheng Jing J He Jie J

Cancer research 20080101 1

Esophageal cancer is the sixth leading cause of death from cancer and one of the least studied cancers worldwide. The global microRNA expression profile of esophageal cancer has not been reported previously. Here, for the first time, we have investigated expressed microRNAs in cryopreserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses identified seven microRNAs that could distinguish malignant esophageal cancer lesions from adjacent normal tiss ...[more]

PMID: 18172293

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