Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Anna Csiszar
PROVIDER: E-GEOD-619 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Csiszar Anna A Ungvari Zoltan Z Koller Akos A Edwards John G JG Kaley Gabor G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030422 9
The phenotypic and functional changes of coronary arteries with aging promote ischemic heart disease. We hypothesized that these alterations reflect an aging-induced proinflammatory shift in vascular regulatory mechanisms. Thus, in isolated coronary arteries of young (3-month-old) and aged (25-month-old) male Fischer 344 rats the expression of 96 cytokines, chemokines, and their receptors were screened by a cDNA-based microarray technique. In aged vessels expressions of tumor necrosis factor (TN ...[more]