Unknown,Transcriptomics,Genomics,Proteomics

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Expression data of mice cochlea treated with L-methionine and valproic acid.


ABSTRACT: Treatment of DBA/2J mice with a combination of L-methionine and valproic acid significantly attenuated progressive hearing loss. We examined gene expression in the whole cochlea of the mice. This study was aimed to detect genes of which change in expression levels were associated with attenuation of progressive hearing loss in the mice. DBA/2J mice at 4 weeks old (untreated_4-weeks, N=5), mice treated with control vehicle (0.1M sodium bicarbonate) for 8 weeks (Control_vehicle_12-weeks, N=5), and mice treated with L-methionine and valproic acid (MET_and_VA_12-weeks, N=6) were analyzed.

ORGANISM(S): Mus musculus

SUBMITTER: Fuyuki Miya 

PROVIDER: E-GEOD-62173 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4.

Mutai Hideki H   Miya Fuyuki F   Fujii Masato M   Tsunoda Tatsuhiko T   Matsunaga Tatsuo T  

PloS one 20150414 4


Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory pathways, which can be modified by environmental factors, could modulate hearing. RT-PCR detected expression of genes encoding DNA methyltransferase and histone deacetylase (Hdac) in the postnatal as well as adult mouse auditory epithelium. DBA/2J mice, which are a model for progressive hearing loss, were injected subcutaneously with one o  ...[more]

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