Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Inhibition of the autocrine loop IL6-JAK2-STAT3-Calprotectin as targeted therapy for HR-/HER2+ breast cancers

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Jiyang Yu

PROVIDER: E-GEOD-62251 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers.

Rodriguez-Barrueco Ruth R Yu Jiyang J Saucedo-Cuevas Laura P LP Olivan Mireia M Llobet-Navas David D Putcha Preeti P Castro Veronica V Murga-Penas Eva M EM Collazo-Lorduy Ana A Castillo-Martin Mireia M Alvarez Mariano M Cordon-Cardo Carlos C Kalinsky Kevin K Maurer Matthew M Califano Andrea A Silva Jose M JM

Genes & development 20150730 15

HER2-positive (HER2(+)) breast adenocarcinomas are a heterogeneous group in which hormone receptor (HR) status influences therapeutic decisions and patient outcome. By combining genome-wide RNAi screens with regulatory network analysis, we identified STAT3 as a critically activated master regulator of HR(-)/HER2(+) tumors, eliciting tumor dependency in these cells. Mechanistically, HR(-)/HER2(+) cells secrete high levels of the interleukin-6 (IL-6) cytokine, inducing the activation of STAT3, whi ...[more]

PMID: 26227964

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Dataset Information

Inhibition of the autocrine loop IL6-JAK2-STAT3-Calprotectin as targeted therapy for HR-/HER2+ breast cancers

Publications

Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers.

Similar Datasets

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