Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Testu Akiyama
PROVIDER: E-GEOD-62316 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Scientific reports 20150921
The transcription factor GATA6 is a critical regulator of cell proliferation and development in the gastrointestinal tract. We have recently reported that GATA6 induces the expression of the intestinal stem cell marker LGR5 and enhances the clonogenicity and tumorigenicity of colon cancer cells, but not the growth of these cells cultured under adherent conditions. Here we show that REG4, a member of the regenerating islet-derived (REG) family, is also a target of GATA6. We further demonstrate th ...[more]