Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Pierre Martineau
PROVIDER: E-GEOD-62321 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Del Rio Maguy M Molina Franck F Bascoul-Mollevi Caroline C Copois Virginie V Bibeau Frédéric F Chalbos Patrick P Bareil Corinne C Kramar Andrew A Salvetat Nicolas N Fraslon Caroline C Conseiller Emmanuel E Granci Virginie V Leblanc Benjamin B Pau Bernard B Martineau Pierre P Ychou Marc M
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070301 7
<h4>Purpose</h4>In patients with advanced colorectal cancer, leucovorin, fluorouracil, and irinotecan (FOLFIRI) is considered as one of the reference first-line treatments. However, only about half of treated patients respond to this regimen, and there is no clinically useful marker that predicts response. A major clinical challenge is to identify the subset of patients who could benefit from this chemotherapy. We aimed to identify a gene expression profile in primary colon cancer tissue that co ...[more]