Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Thomas De Raedt
PROVIDER: E-GEOD-62500 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
De Raedt Thomas T Beert Eline E Pasmant Eric E Luscan Armelle A Brems Hilde H Ortonne Nicolas N Helin Kristian K Hornick Jason L JL Mautner Victor V Kehrer-Sawatzki Hildegard H Clapp Wade W Bradner James J Vidaud Michel M Upadhyaya Meena M Legius Eric E Cichowski Karen K
Nature 20140813 7521
The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types. However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies, suggesting that this complex plays a dichotomous and poorly understood role in cancer. Here we provide genomic, cellular, and mouse modelling data demonstrating that the polycomb group gene SUZ12 functions as tumour suppressor in PNS tumours, high-grade gliomas and melanomas by cooperating with mutations i ...[more]