Gata6 network regulates epidermal junctional zone cell fate.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Giacomo Donati
PROVIDER: E-GEOD-62608 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Wounding induces dedifferentiation of epidermal Gata6<sup>+</sup> cells and acquisition of stem cell properties.
Donati Giacomo G Rognoni Emanuel E Hiratsuka Toru T Liakath-Ali Kifayathullah K Hoste Esther E Kar Gozde G Kayikci Melis M Russell Roslin R Kretzschmar Kai K Mulder Klaas W KW Teichmann Sarah A SA Watt Fiona M FM
Nature cell biology 20170515 6
The epidermis is maintained by multiple stem cell populations whose progeny differentiate along diverse, and spatially distinct, lineages. Here we show that the transcription factor Gata6 controls the identity of the previously uncharacterized sebaceous duct (SD) lineage and identify the Gata6 downstream transcription factor network that specifies a lineage switch between sebocytes and SD cells. During wound healing differentiated Gata6<sup>+</sup> cells migrate from the SD into the interfollicu ...[more]
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