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Characterization of genomic alterations in radiation-related breast cancer among childhood cancer survivors, using comparative genomic hybridization (CGH) arrays

ABSTRACT: Evaluation of aCGH profile of 32 breast tumors from the childhood cancer survivor study Breast cancer cases, most of them received high-dose chest radiation during childhood for the treatment of their first cancers

ORGANISM(S): Homo sapiens

SUBMITTER: Rose Yang

PROVIDER: E-GEOD-62940 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Characterization of genomic alterations in radiation-related breast cancer among childhood cancer survivors, using comparative genomic hybridization (CGH) arrays

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Project description:Inflammatory breast cancer (IBC) is a unique clinical entity characterized by rapid onset of erythema and swelling of the breast often without an obvious breast mass. Many studies have examined and compared gene expression between IBC and non-IBC (nIBC), repeatedly finding clusters associated with receptor subtype, but no consistent gene signature associated with IBC has been validated. Here we examined microdissected IBC tumor cells compared to microdissected nIBC tumor cells matched based on estrogen and HER-2/neu receptor status. Genomic profiling of 20 inflammatory breast cancer (IBC), 20 non-IBC and 5 normal was studied.

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