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Transcription profiling of rat keratinocytes exposed to a 56Fe ion beam

ABSTRACT: The purpose of the present work was to examine gene expression patterns in a rat keratinocyte line exposed to a 56Fe ion beam Experiment Overall Design: The cells were exposed to 1.01 geV/nucleon 56Fe ions generated by the NASA Space Radiation Laboratory facility. Data from Affymetrix rat microarrays (RAT 230_2) were processed by BRB ArrayTools 3.3.0 software, and the Gene Ontogeny (GO) database was utilized to categorize significantly responding genes.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ronghe Zhang

PROVIDER: E-GEOD-6299 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression and cell cycle arrest in a rat keratinocyte line exposed to 56Fe ions.

Wu Feng F Zhang Ronghe R Burns Fredric J FJ

Journal of radiation research 20070301 2

The purpose of the present work was to examine gene expression patterns in a rat keratinocyte line exposed to a (56)Fe ion beam. The cells were exposed to 1.01 geV/nucleon (56)Fe ions generated by the NASA Space Radiation Laboratory facility. Data from Affymetrix rat microarrays (RAT 230_2) were processed by BRB ArrayTools 3.3.0 software, and the Gene Ontogeny (GO) database was utilized to categorize significantly responding genes. Cell cycle distribution was analyzed by flow cytometry, and cell ...[more]

PMID: 17392591

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