Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yi-Chien Lu
PROVIDER: E-GEOD-63199 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lu Yi-Chien YC Chang Sung-Hee SH Hafner Markus M Li Xi X Tuschl Thomas T Elemento Olivier O Hla Timothy T
Cell reports 20141218 6
Posttranscriptional gene regulation by miRNAs and RNA binding proteins (RBP) is important in development, physiology, and disease. To examine the interplay between miRNAs and the RBP ELAVL1 (HuR), we mapped miRNA binding sites at the transcriptome-wide scale in wild-type and Elavl1 knockout murine bone-marrow-derived macrophages. Proximity of ELAVL1 binding sites attenuated miRNA binding to transcripts and promoted gene expression. Transcripts that regulate angiogenesis and macrophage/endothelia ...[more]